Article
NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis.
Nitric oxide : biology and chemistry - 1 Jan 2000
Varadé Jezabel, Lamas José Ramón, Fernández-Arquero Miguel, Jover Juan Angel, de la Concha Emilio G, Martínez Alfonso, Fernández-Gutierrez Benjamín, Urcelay Elena
Abstract excerpt
Nitric oxide has been described as a trigger for the synthesis of proinflammatory mediators and as a cytotoxic molecule with a pivotal role in apoptosis at the joints of rheumatoid arthritis (RA) patients. Polymorphisms in the NOS2A gene, which codes for the inducible nitric oxide synthase [(i)NOS], have been tested for association with several autoimmune diseases such as Crohn's disease or type 1 diabetes....
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