Article
Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients.
Disease markers - 1 Jan 2009
Bohanec Grabar Petra, Logar Dussan, Tomsic Matija, Rozman Blaz, Dolzan Vita
Abstract excerpt
Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT) (n)polymorphisms in 327 RA...
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