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Article

Polymorphisms in the promoter region of iNOS predispose to rheumatoid arthritis in south Indian Tamils.

International journal of immunogenetics - 1 Jun 2017

Negi V S, Mariaselvam C M, Misra D P, Muralidharan N, Fortier C, Charron D, Krishnamoorthy R, Tamouza R

Abstract excerpt

Nitric oxide synthase (NOS) catalyses the production of nitric oxide (NO) from L-Arginine, which participates in diverse biological processes including inflammation and apoptosis. Macrophages, chondrocytes, osteoblasts and osteoclasts express inducible NOS (iNOS) at the site of synovial inflammation. NO produced at the inflamed joint may contribute to peri-articular bone loss, mediate apoptosis and regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 28374504
DOI: 10.1111/iji.12315

Genes

NOS2
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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