Article
NOS2A as a candidate gene in Relapsing-Remitting Multiple Sclerosis: a haplotype study using selected subsets of single nucleotide polymorphisms.
Journal of the neurological sciences - 15 May 2011
Manna Ida, Liguori Maria, Valentino Paola, Vena Luana, Condino Francesca, Nisticò Rita, Di Palma Gemma, Quattrone Aldo, Gambardella Antonio
Abstract excerpt
As with other autoimmune diseases, susceptibility to multiple sclerosis (MS) is believed to result from the complex interaction of a number of genes, each with modest effect. Several genome-wide screens have implicated the nitric oxide synthase 2A gene (NOS2A), which encodes the inducible form of nitric oxide synthase, as being potentially associated with MS. To determine whether genetic variants within this gene...
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