Article
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells.
The Journal of steroid biochemistry and molecular biology - 1 Oct 2009
Singh Seema, Zahid Muhammad, Saeed Muhammad, Gaikwad Nilesh W, Meza Jane L, Cavalieri Ercole L, Rogan Eleanor G, Chakravarti Dhrubajyoti
Abstract excerpt
Estrogens (estrone, E(1); estradiol, E(2)) are oxidized in the breast first to catechols and then to form two ortho-quinones (E(1/2)-3,4-Q) that react with DNA to form depurinating adducts, which lead to mutations associated with breast cancer. NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. We examined whether the inheritance of two...
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