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Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53.

Human molecular genetics - 1 Jul 2009

Yu Ke-Da, Di Gen-Hong, Yuan Wen-Tao, Fan Lei, Wu Jiong, Hu Zhen, Shen Zhen-Zhou, Zheng Ying, Huang Wei, Shao Zhi-Ming

Abstract excerpt

We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones and its ability to stabilize p53. We performed case-control studies to investigate the contributions of genetic variants/haplotypes of the NQO2 gene to breast cancer risk. In the first hospital-based study (n = 1604), we observed...

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PMID: 19351655
DOI: 10.1093/hmg/ddp171

Genes

NQO2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53.PMID 19351655Read ↗

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