Article
Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53.
Human molecular genetics - 1 Jul 2009
Yu Ke-Da, Di Gen-Hong, Yuan Wen-Tao, Fan Lei, Wu Jiong, Hu Zhen, Shen Zhen-Zhou, Zheng Ying, Huang Wei, Shao Zhi-Ming
Abstract excerpt
We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones and its ability to stabilize p53. We performed case-control studies to investigate the contributions of genetic varian...
Topics
- Adult
- Asian People
- Base Sequence
- Breast Neoplasms
- Case-Control Studies
- Cell Line, Tumor
- China
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Middle Aged