Article
Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2004
Fowke Jay H, Shu Xiao-Ou, Dai Qi, Jin Fan, Cai Qiuyin, Gao Yu-Tang, Zheng Wei
Abstract excerpt
Despite intensive study, the relationship between oral contraception (OC) and breast cancer remains unclear. OCs contain a potent synthetic estrogen (ethinyl estradiol) but lower endogenous estradiol levels, and ethinyl estradiol is a weak progenitor of semiquinones, catechol estrogens capable of...
Topics
- Adult
- Age Distribution
- Base Sequence
- Breast Neoplasms
- Case-Control Studies
- China
- Confidence Intervals
- Contraceptives, Oral, Hormonal
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Middle Aged
- Molecular Sequence Data