Article
The association between NQO1 Pro187Ser polymorphism and bladder cancer susceptibility: a meta-analysis of 15 studies.
PloS one - 1 Jan 2015
Yang Sen, Jin Tao, Su Hong-Xia, Zhu Jin-Hong, Wang Da-Wen, Zhu Shi-Jian, Li Sheng, He Jing, Chen Ying-He
Abstract excerpt
BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), an obligate two-electron reductase, plays an important role in reducing reactive quinones to less reactive and less toxic hydroquinones. Genetic variations in NQO1 gene that impede its enzyme function may be considered as putative risk factor...
Topics
- Asian People
- Genetic Predisposition to Disease
- Genotype
- Humans
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Genetic
- Urinary Bladder Neoplasms