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Article

Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women.

Genetic testing and molecular biomarkers - 1 May 2011

Singh Virendra, Upadhyay Ghanshyam, Rastogi Neeraj, Singh Kalpana, Singh Mahendra Pratap

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) and cytochrome P450 1A2 (CYP1A2) are involved in the metabolism of estrogens. Genetic polymorphisms in these genes may lead to interindividual variation in breast cancer susceptibility. This study was undertaken to investigate the association of NQO1 exon 6 proline187serine (C609T) and CYP1A2 exon 2 phenylalanine21leucine (C63G) polymorphisms with breast cancer...

Topics

Adult
Breast Neoplasms
Cytochrome P-450 CYP1A2
Female
Genetic Predisposition to Disease
Genotype
Humans
Inactivation, Metabolic
India
Middle Aged
NAD(P)H Dehydrogenase (Quinone)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

White People

Xenobiotics

Source

Identifiers

PMID: 21329464
DOI: 10.1089/gtmb.2010.0197

Genes

NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21329464-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women.PMID 21329464Read ↗

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