Article
The NQO1 Pro187Ser polymorphism and breast cancer susceptibility: evidence from an updated meta-analysis.
Diagnostic pathology - 29 May 2014
Peng Qiliu, Lu Yu, Lao Xianjun, Chen Zhiping, Li Ruolin, Sui Jingzhe, Qin Xue, Li Shan
Abstract excerpt
BACKGROUND NAD(P)H: quinone oxidoreductase 1 (NQO1) plays a central role in catalyzing the two-electron reduction of quinoid compounds into hydroquinones. The NQO1 Pro187Ser polymorphism was found to correlate with a lower enzymatic activity, which may result in increased incidence of carcinomas...
Topics
- Breast Neoplasms
- Case-Control Studies
- Chi-Square Distribution
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- NAD(P)H Dehydrogenase (Quinone)
- Odds Ratio
- Phenotype
- Polymorphism, Genetic
- Risk Assessment
- Risk Factors
- White People