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Article

Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma.

Oncology reports - 1 Oct 2005

Singh Seema, Chakravarti Dhrubajyoti, Edney James A, Hollins Ronald R, Johnson Perry J, West William W, Higginbotham Sheila M, Cavalieri Ercole L, Rogan Eleanor G

Abstract excerpt

Estrogens are a known risk factor for breast cancer. Studies indicate that initiation of breast cancer may occur by metabolism of estrogens to form abnormally high levels of catechol estrogen-3,4-quinones, which can then react with DNA to form depurinating adducts and, subsequently, induce mutations that lead to cancer. Among the key enzymes metabolizing estrogens are two activating enzymes: cytochrome P450...

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Identifiers

PMID: 16142378

Genes

COMT
NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma.PMID 16142378Read ↗

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