Article
NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Pharmacogenetics - 1 Aug 1998
Gaedigk A, Tyndale R F, Jurima-Romet M, Sellers E M, Grant D M, Leeder J S
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) catalyses the two-electron reduction of quinone compounds. NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Three alleles have been identified in the human population: the functional Arg139/Pro187...
Topics
- Alleles
- Asian People
- Base Sequence
- Canada
- China
- Gene Frequency
- Genotype
- Humans
- Indians, North American
- Molecular Sequence Data
- NAD(P)H Dehydrogenase (Quinone)