Article

Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric <i>p</i> -Phenylene Ethynylenes

2021-11-04

Abstract excerpt

Photodynamic therapy (PDT) has been explored as a therapeutic strategy to clear toxic amyloid aggregates involved in neurodegenerative disorders such as Alzheimer’s disease. A major limitation of PDT is off-target oxidation, which can be lethal for the surrounding cells. We have shown that a novel class of oligo- p -phenylene ethynylene-based compounds (OPEs) exhibit selective binding and fluorescence turn-on in...

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Literature Corpus work: 04833226-8633-5790-9c14-a3306783c4b1
DOI: 10.1101/2021.11.03.467121

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