Article
Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain.
ASN neuro - 1 Jan 2022
Adeniyi Philip A, Fopiano Katie-Anne, Banine Fatima, Garcia Mariel, Gong Xi, Keene C Dirk, Sherman Larry S, Bagi Zsolt, Back Stephen A
Abstract excerpt
A major limitation of mechanistic studies in aging brains is the lack of routine methods to robustly visualize and discriminate the cellular distribution of tissue antigens using fluorescent immunohistochemical multi-labeling techniques. Although such approaches are routine in non-aging brains, they are not consistently feasible in the aging brain due to the progressive accumulation of autofluorescent pigments,...
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