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Thioflavin-S staining coupled to flow cytometry. A screening tool to detect <i>in vivo</i> protein aggregation

24 Jul 2012

Abstract excerpt

Amyloid deposits are associated with an increasing number of human disorders, including Alzheimer's and Parkinson's diseases. Recent studies provide compelling evidence for the existence of amyloid-like conformations in the insoluble bacterial inclusion bodies (IBs) produced during the recombinant expression of amyloidogenic proteins. This makes prokaryotic cells a physiologically relevant system to study the...

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PMID: 22868714
DOI: 10.1039/c2mb25214g

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