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In vitro and in vivo Staining Characteristics of Small, Fluorescent, Aβ42‐Binding <scp>D</scp>‐Enantiomeric Peptides in Transgenic AD Mouse Models

15 Dec 2008

Abstract excerpt

Abstract Plaque visualisation : We identified three different D ‐enantiomeric peptides that bind to Alzheimer's amyloid β (Aβ1‐42). As there is currently no definitive pre‐mortem diagnosis for Alzheimer's disease, we investigated the peptides' suitability as molecular probes for in vivo imaging in transgenic mouse models. magnified image One of the characteristic pathological hallmarks of Alzheimer's disease (AD)...

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PMID: 19072935
DOI: 10.1002/cmdc.200800289

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