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Article

Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.

Molecular cell - 11 Sept 2009

Shen Xi, Do Huong, Li Yongjiang, Chung Woo-Hyun, Tomasz Maria, de Winter Johan P, Xia Bing, Elledge Stephen J, Wang Weidong, Li Lei

Abstract excerpt

Fanconi anemia (FA) is characterized by cellular hypersensitivity to DNA crosslinking agents, but how the Fanconi pathway protects cells from DNA crosslinks and whether FA proteins act directly on crosslinks remain unclear. We developed a chromatin-IP-based strategy termed eChIP and detected association of multiple FA proteins with DNA crosslinks in vivo. Interdependence analyses revealed that crosslink-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19748364
DOI: 10.1016/j.molcel.2009.06.034
PMCID: PMC2758766

Genes

BACH1
BRCA2
FANCD2
PALB2
XPA
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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