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DNA crosslinking damage and cancer - a tale of friend and foe.

1 Jun 2013

Abstract excerpt

Interstrand crosslinks (ICLs) represent a major challenge for DNA replication and transcription by preventing DNA strand separation. Cells deficient in ICL repair are hypersensitive to a variety of bifunctional alkylating agents and exhibit excessive genomic instability. Patients with deficient ICL repair, such as those with Fanconi anemia, are predisposed to a broad spectrum of cancers. The profound cellular...

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PMID: 23998004
DOI: 10.3978/j.issn.2218-676x.2013.03.01

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