Article
[Mutation and abnormal expression of FHIT gene in hypopharyngeal carcinoma].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery - 1 Mar 2009
Wu Hao, Luan Xinyong, Pan Xinliang, Huang Jianfei, Wang Qiang, Lei Dapeng
Abstract excerpt
OBJECTIVE: To analyze the mutation and abnormal expression of the FHIT gene in human hypopharyngeal carcinoma. METHOD: Matched normal and cancerous tissues from 24 patients with hypopharyngeal squamous cell carcinoma were obtained immediately after surgery. Total RNA was extracted, the FHIT gene was detected by nested RT-PCR and DNA sequencing technology. RESULT: Normal sized FHIT transcript was detected in 23 of...
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