Article
[Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Jun 2002
Wang Yun, Zhuo Qinghua, Qin Yang, Yuan Shulan, Sun Zhilin, Wang Yanping, Chen Xiaohe, Sun Zefang, Song Yi, Yang Yan
Abstract excerpt
OBJECTIVE: To explore the role of fragile histidine triad(FHIT) gene in the proliferation, apoptosis and tumorigenesis of human lung cancer cells. METHODS: FHIT gene packaged with lipofectin was transfected into the cells of a human lung adenocarcinoma cell line (A549), which stably expressed ectogenous FHIT gene. The FHIT mRNA and protein expression of A549-FHIT, A549-vector and A549 cell were detected by...
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