Article
Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.
International journal of oncology - 1 Jul 1999
Sato H, Hiyama K, Ishioka S, Maeda H, Yamakido M
Abstract excerpt
The FHIT gene is considered to be a tumor suppressor gene, its role and inactivation mechanism remain unclear. We analyzed FHIT gene aberrations in 64 lung cancer tissues and found that the appearance of the aberrant FHIT transcripts depends on the condition of RT-PCR and high telomerase activity, shortened telomere length, and advanced pathological stage were likely associated with the prevalence of aberrant...
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