Article
Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague.
Infection and immunity - 1 Feb 2011
Ye Zhan, Uittenbogaard Annette M, Cohen Donald A, Kaplan Alan M, Ambati Jayakrishna, Straley Susan C
Abstract excerpt
We are using a systemic plague model to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this study, we pursued previous findings that Gr1(+) cells are required to selectively limit growth of ΔyopM Y. pestis and that CD11b(+) cells other than polymorphonuclear leukocytes (PMNs) are selectively lost in spleens infected with parent Y....
Topics
- Animals
- Antigens, Ly
- Bacterial Outer Membrane Proteins
- CD11b Antigen
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Liver
- Mice
- Mice, Inbred C57BL
- Mutation
- Neutrophils
- Plague
- Receptors, CCR2