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<i>Toxoplasma</i> induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1

2025-03-17

Abstract excerpt

Acute virulence in Toxoplasma gondii is linked to an excessive proinflammatory cytokine cascade during laboratory murine infection. Previous work showed that T. gondii secretes a pore forming protein, PLP1, that is required for efficient cytolytic egress from host cells. Deletion of the PLP1 gene results in defective egress from infected culture cells and a marked reduction in parasite virulence. The goal of th...

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Literature Corpus work
a9a417c9-4ab9-50be-8133-2aad055b17e9
DOI
10.1101/2025.03.17.643671
Open publication

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