Article
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.
Biophysical journal - 22 Jul 2009
Montel Fabien, Menoni Hervé, Castelnovo Martin, Bednar Jan, Dimitrov Stefan, Angelov Dimitar, Faivre-Moskalenko Cendrine
Abstract excerpt
Chromatin organization and dynamics is studied at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique, and numerical modeling. We show that a subtle modification in the nucleosome structure induced by the histone variant H2A.Bbd drastically modifies the higher order organization of the nucleosomal arrays. Importantly, as...
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