Article
Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.
Molecular cell - 17 Aug 2017
Kieffer-Kwon Kyong-Rim, Nimura Keisuke, Rao Suhas S P, Xu Jianliang, Jung Seolkyoung, Pekowska Aleksandra, Dose Marei, Stevens Evan, Mathe Ewy, Dong Peng, Huang Su-Chen, Ricci Maria Aurelia, Baranello Laura, Zheng Ying, Tomassoni Ardori Francesco, Resch Wolfgang, Stavreva Diana, Nelson Steevenson, McAndrew Michael, Casellas Adriel, Finn Elizabeth, Gregory Charles, St Hilaire Brian Glenn, Johnson Steven M, Dubois Wendy, Cosma Maria Pia, Batchelor Eric, Levens David, Phair Robert D, Misteli Tom, Tessarollo Lino, Hager Gordon, Lakadamyali Melike, Liu Zhe, Floer Monique, Shroff Hari, Aiden Erez Lieberman, Casellas Rafael
Abstract excerpt
50 years ago, Vincent Allfrey and colleagues discovered that lymphocyte activation triggers massive acetylation of chromatin. However, the molecular mechanisms driving epigenetic accessibility are still unknown. We here show that stimulated lymphocytes decondense chromatin by three differentially regulated steps. First, chromatin is repositioned away from the nuclear periphery in response to global acetylation....
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