Article

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

2023-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Affective or mood disorders are a leading cause of disability worldwide. The serotonergic system has been heavily implicated in the complex etiology and serves as a therapeutic target. The serotonin transporter (SERT) is a major regulator of serotonin neurotransmission, yet the disease-relevance of impaired SERT function remains unknown. Here, we present the first identification and functional ch...

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Literature Corpus work: 57fe26d7-08e4-5c0a-9349-512b6138009a
DOI: 10.1101/2023.08.29.23294386

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