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Article

XPC is involved in genome maintenance through multiple pathways in different tissues.

Mutation research - 2 Nov 2009

Uehara Yoshihiko, Ikehata Hironobu, Furuya Maiko, Kobayashi Sayaka, He Dongwei, Chen Yali, Komura Jun-Ichiro, Ohtani Hiroshi, Shimokawa Isao, Ono Tetsuya

Abstract excerpt

In an attempt to evaluate the role of the Xpc gene in maintaining genomic stability in vivo under normal conditions, the age-dependent accumulation of spontaneous mutations in different tissues was analyzed in Xpc-deficient lacZ-transgenic mice. Brain, testis, and small intestine revealed no effects from the Xpc-deficiency, whereas liver, spleen, heart, and lung showed an enhanced age-related accumulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Xeroderma Pigmentosum

Source

Identifiers

PMID: 19615386
DOI: 10.1016/j.mrfmmm.2009.06.018

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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