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Article

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.

Mutation research - 11 Apr 2006

Dollé Martijn E T, Busuttil Rita A, Garcia Ana Maria, Wijnhoven Susan, van Drunen Ellen, Niedernhofer Laura J, van der Horst Gijsbertus, Hoeijmakers Jan H J, van Steeg Harry, Vijg Jan

Abstract excerpt

Genetic defects in nucleotide excision repair (NER) are associated with premature aging, including cancer, in both humans and mice. To investigate the possible role of increased somatic mutation accumulation in the accelerated appearance of symptoms of aging as a consequence of NER deficiency, we crossed four different mouse mutants, Xpa-/-, Ercc6(Csb)-/-, Ercc2(Xpd)m/m and Ercc1-/m, with mice harboring...

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Identifiers

PMID: 16472827
DOI: 10.1016/j.mrfmmm.2005.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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