Article
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair.
Oncogene - 12 Oct 2000
Wijnhoven S W, Kool H J, Mullenders L H, van Zeeland A A, Friedberg E C, van der Horst G T, van Steeg H, Vrieling H
Abstract excerpt
DNA damages caused by cellular metabolites and environmental agents induce mutations, that may predispose to cancer. Nucleotide excision repair (NER) is a major cellular defence mechanism acting on a variety of DNA lesions. Here, we show that spontaneous mutant frequencies at the Hprt gene increased 30-fold in T-lymphocytes of 1 year old Xpc-/- mice, possessing only functional transcription-coupled repair (TCR)....
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