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Article

Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.

DNA repair - 1 Dec 2013

Melis Joost P M, Kuiper Raoul V, Zwart Edwin, Robinson Joke, Pennings Jeroen L A, van Oostrom Conny T M, Luijten Mirjam, van Steeg Harry

Abstract excerpt

XPC is one of the key DNA damage recognition proteins in the global genome repair route of the nucleotide excision repair (NER) pathway. Previously, we demonstrated that NER-deficient mouse models Xpa(-/-) and Xpc(-/-) exhibit a divergent spontaneous tumor spectrum and proposed that XPC might be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24084170
DOI: 10.1016/j.dnarep.2013.08.019
PMCID: PMC3847164

Genes

XPC
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24084170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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