The role of XPC: implications in cancer and oxidative DNA damage.

doi:10.1016/j.mrrev.2011.07.001

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Article

The role of XPC: implications in cancer and oxidative DNA damage.

Mutation research - 1 Jan 2000

Melis Joost P M, Luijten Mirjam, Mullenders Leon H F, van Steeg Harry

Abstract excerpt

The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging features and cancer. One of the most versatile and important defense mechanisms against the accumulation of DNA damage is nucleotide excision repair (NER), in which the Xeroderma pigmentosum group C (XPC) protein plays a prominent role. NER can be divided into global genome repair (GG-NER) and...

Topics

Aging
Animals
Cell Cycle Checkpoints
DNA Damage
DNA Repair
DNA-Binding Proteins
Disease Models, Animal
Humans
Mice
Neoplasms
Polymorphism, Single Nucleotide
Xeroderma Pigmentosum

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PMID: 21763452
DOI: 10.1016/j.mrrev.2011.07.001
PMCID: PMC3203325

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