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Article

Frequent recovery of triplet mutations in UVB-exposed skin epidermis of Xpc-knockout mice.

DNA repair - 4 Jan 2007

Ikehata Hironobu, Saito Yusuke, Yanase Fumitaka, Mori Toshio, Nikaido Osamu, Ono Tetsuya

Abstract excerpt

Mutations of the Xpc gene cause a deficiency in global genome repair, a subpathway of nucleotide excision repair (NER), in mammalian cells. We used transgenic mice harboring the lambda-phage-based lacZ mutational reporter gene to study the effect of an Xpc null mutation (Xpc-/-) on damage induction, repair and mutagenesis in mouse skin epidermis after UVB irradiation. UVB induced equal amounts of cyclobutane...

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Identifiers

PMID: 17049932
DOI: 10.1016/j.dnarep.2006.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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