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Article

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.

Cancer research - 1 Mar 2008

Melis Joost P M, Wijnhoven Susan W P, Beems Rudolf B, Roodbergen Marianne, van den Berg Jolanda, Moon Hojin, Friedberg Errol, van der Horst Gijsbertus T J, Hoeijmakers Jan H J, Vijg Jan, van Steeg Harry

Abstract excerpt

The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging, and cancer. One of the most versatile defense mechanisms against the accumulation of DNA damage is nucleotide excision repair, in which, among others, the Xeroderma pigmentosum group C (XPC) and group A (XPA) proteins are involved. To elucidate differences in the functions of these two proteins,...

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Identifiers

PMID: 18316597
DOI: 10.1158/0008-5472.CAN-07-6067

Genes

XPC
XPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.PMID 18316597Read ↗

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