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Article

Spontaneous mutations in digestive tract of old mice show tissue-specific patterns of genomic instability.

Cancer research - 1 Oct 2004

Ono Tetsuya, Ikehata Hironobu, Pithani Vishnu Priya, Uehara Yoshihiko, Chen Yali, Kinouchi Yoshitaka, Shimosegawa Toru, Hosoi Yoshio

Abstract excerpt

In an attempt to evaluate the possible role of mutations in the age-dependent increase of tumor incidence, we studied the mutational burden that accumulates in the aging process in different parts of the digestive tract in mice. The mutations were monitored in lacZ genes integrated in the mouse g...

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Identifiers

PMID: 15466182
DOI: 10.1158/0008-5472.CAN-04-1476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15466182-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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