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Article

The <scp>DACH/EYA/SIX</scp> gene network and its role in tumor initiation and progression

9 Apr 2015

Abstract excerpt

The functional abnormality of developmental genes is a common phenomenon in cancer initiation and progression. The retinal determination gene network (RDGN) is a key signal in Drosophila eye specification, and this conservative pathway is also required for the development of multiple organs in mammalian species. Recent studies demonstrated that aberrant expressions of RDGN components in vertebrates, mainly Dach,...

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PMID: 26096807
DOI: 10.1002/ijc.29560

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