Article
Regression based predictor for p53 transactivation.
BMC bioinformatics - 14 Jul 2009
Gowrisankar Sivakumar, Jegga Anil G
Abstract excerpt
BACKGROUND: The p53 protein is a master regulator that controls the transcription of many genes in various pathways in response to a variety of stress signals. The extent of this regulation depends in part on the binding affinity of p53 to its response elements (REs). Traditional profile scores for p53 based on position weight matrices (PWM) are only a weak indicator of binding affinity because the level of...
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