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Article

The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.

The Journal of cell biology - 13 Jul 2009

Sawyer Jessica K, Harris Nathan J, Slep Kevin C, Gaul Ulrike, Peifer Mark

Abstract excerpt

Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the cytoskeleton. Mammalian afadin has been suggested to be essential for adhesion and polarity establishment, but its mechanism of action is unclear. In contrast, Drosophila melanogaster's afadin homologue Canoe (Cno) has suggested roles in signal transduction...

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Identifiers

PMID: 19596848
DOI: 10.1083/jcb.200904001
PMCID: PMC2712996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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