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Article

Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis.

The Journal of cell biology - 6 Dec 2021

Perez-Vale Kia Z, Yow Kristi D, Johnson Ruth I, Byrnes Amy E, Finegan Tara M, Slep Kevin C, Peifer Mark

Abstract excerpt

Embryogenesis requires cells to change shape and move without disrupting epithelial integrity. This requires robust, responsive linkage between adherens junctions and the actomyosin cytoskeleton. Using Drosophila morphogenesis, we define molecular mechanisms mediating junction-cytoskeletal linkage and explore the role of mechanosensing. We focus on the junction-cytoskeletal linker Canoe, a multidomain protein. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34762121
DOI: 10.1083/jcb.202104087
PMCID: PMC8590279

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