Article
Abelson kinase regulates epithelial morphogenesis in Drosophila.
The Journal of cell biology - 24 Dec 2001
Grevengoed E E, Loureiro J J, Jesse T L, Peifer M
Abstract excerpt
Activation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to the development of leukemia, but the complex roles of Abl in normal development are not fully understood. Drosophila Abl links neural axon guidance receptors to the cytoskeleton. Here we report a novel role for Drosophila Abl in epithelial cells, where it is critical for morphogenesis. Embryos completely lacking both maternal and zygotic...
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