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Article

Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.

Developmental biology - 1 Oct 2021

Lesko Alyssa C, Keller Raymond, Chen Ping, Sutherland Ann

Abstract excerpt

Morphogenesis of the vertebrate neural tube occurs by elongation and bending of the neural plate, tissue shape changes that are driven at the cellular level by polarized cell intercalation and cell shape changes, notably apical constriction and cell wedging. Coordinated cell intercalation, apical constriction, and wedging undoubtedly require complex underlying cytoskeletal dynamics and remodeling of adhesions....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34029538
DOI: 10.1016/j.ydbio.2021.05.013
PMCID: PMC8424754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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