Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.

PloS one - 1 Jan 2013

Yamamoto Hideaki, Maruo Tomohiko, Majima Takashi, Ishizaki Hiroyoshi, Tanaka-Okamoto Miki, Miyoshi Jun, Mandai Kenji, Takai Yoshimi

Abstract excerpt

Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell-cell adhesion molecules at AJs are cadherins and nectins. Afadin binds to both nectins and α-catenin and recruits the cadherin-β-catenin complex to the nectin-based cell-cell adhesion site to form AJs. To explore the role of afadin in radial glial and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrocephalus

Share to Mesencephalon

Share to Mice, Knockout

Share to Microfilament Proteins

Share to Neurons

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 24236178
DOI: 10.1371/journal.pone.0080356
PMCID: PMC3827428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.PMID 24236178Read ↗

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.Semantic proximity Read ↗

Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia.Semantic proximity Read ↗

Afadin Loss Uncovers an Ectopic Neurogenic Niche and Reorganizes the Adult Ventricular-Subventricular ZoneSemantic proximity Read ↗

<i>Afadin</i> Loss Uncovers an Ectopic Neurogenic Niche and Reorganizes the Adult Ventricular-Subventricular ZoneSemantic proximity Read ↗

Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.Semantic proximity Read ↗

The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.Semantic proximity Read ↗

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalusSemantic proximity Read ↗

Multiple roles for the Na,K-ATPase subunits, Atp1a1 and Fxyd1, during brain ventricle development.Semantic proximity Read ↗

Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1.Semantic proximity Read ↗

Nectin and Nectin-Like Molecules: Biology and PathologySemantic proximity Read ↗

Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.Semantic proximity Read ↗

Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.