Article
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.
Molecular cell - 10 Jul 2009
Huang Wendy, Ghisletti Serena, Perissi Valentina, Rosenfeld Michael G, Glass Christopher K
Abstract excerpt
Activation of toll-like receptors (TLRs) leads to derepression and subsequent activation of inflammatory response genes that play essential roles in innate and acquired immunity. Derepression requires signal-dependent turnover of the nuclear receptor corepressor NCoR from target promoters, but the mechanisms remain poorly understood. Here, we report that TLR4 uses NFkappaB to deliver IKKepsilon to target...
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