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Article

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.

Molecular immunology - 1 Sept 2008

Wang Dongmei, Fasciano Stephan, Li Liwu

Abstract excerpt

IRAK-1 is a critical modulator regulating innate immunity signaling processes. However, the physiological substrates for IRAK-1 remain poorly defined. In this report, we have demonstrated that IRAK-1 is a kinase responsible for the constitutive phosphorylation and inactivation of the Nuclear Factor of Activated T-cell (NFAT). Expression of IRAK-1 suppressed NFAT reporter activity. Correspondingly, the levels of...

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Identifiers

PMID: 18691762
DOI: 10.1016/j.molimm.2008.06.023
PMCID: PMC2579773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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