Article

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution

2026-04-30

Abstract excerpt

The clearance of apoptotic cells by macrophages, termed efferocytosis, reprograms macrophages to a resolution/repair phenotype, and pathologic defects in efferocytosis drive many chronic inflammatory diseases. Previous studies have elucidated numerous downstream pro-resolving pathways activated by efferocytosis, but whether there exists a common upstream trigger of these pathways remains unknown. Here, we report t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66c92452-58fd-52d6-b823-fa6b074a1a51
DOI: 10.64898/2026.04.27.720940

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolutionDOI 10.64898/2026.04.27.720940Read

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory ResponsesSemantic proximity Read

Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?Semantic proximity Read

Evaluating the differential expression of TAM family receptors and efferocytosis activities in differentiated and polarized THP-1 macrophageSemantic proximity Read

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and ActivationSemantic proximity Read

ITK Deficiency Attenuates Alveolar Hemorrhage by Enhancing Regulatory T Cell-Mediated Tissue ResilienceSemantic proximity Read

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injurySemantic proximity Read

Decoding Cell Death Signals in Inflammation and ImmunitySemantic proximity Read

No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologiesSemantic proximity Read

Efferocytosis and Its Role in Inflammatory DisordersSemantic proximity Read

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarizationSemantic proximity Read

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.Semantic proximity Read

Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse modelSemantic proximity Read