Article
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.
Nature communications - 2 Mar 2021
Shi Hexin, Sun Lei, Wang Ying, Liu Aijie, Zhan Xiaoming, Li Xiaohong, Tang Miao, Anderton Priscilla, Hildebrand Sara, Quan Jiexia, Ludwig Sara, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
Many immune responses depend upon activation of NF-κB, an important transcription factor in the elicitation of a cytokine response. Here we show that N4BP1 inhibits TLR-dependent activation of NF-κB by interacting with the NF-κB signaling essential modulator (NEMO, also known as IκB kinase γ) to attenuate NEMO-NEMO dimerization or oligomerization. The UBA-like (ubiquitin associated-like) and CUE-like (ubiquitin...
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