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Article

No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis.

The Journal of biological chemistry - 11 Sept 2009

Pores-Fernando Arun T, Ranaghan Michelle Y D, Zweifach Adam

Abstract excerpt

Cytotoxic T cells kill virus-infected cells and tumor cells by releasing lytic granules that contain cell-killing contents. Exocytosis requires calcium influx and protein kinase C (PKC) activation. Here, we extend our previous finding regarding the lack of isoform specificity of PKCs in the granule release step, showing that mutant constitutively active PKCdelta can substitute for phorbol esters and support...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19592494
DOI: 10.1074/jbc.M109.011866
PMCID: PMC2757214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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