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Article

Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function.

Biochemical and biophysical research communications - 1 Aug 2008

Doran Graeme, Davies Kay E, Talbot Kevin

Abstract excerpt

Mutations in protein kinase Cgamma (PKCgamma) cause the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14). In this study, expression of an extensive panel of known SCA14-associated PKCgamma mutations as fusion proteins in cell culture led to the consistent formation of cytoplasmic...

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Identifiers

PMID: 18503760
DOI: 10.1016/j.bbrc.2008.05.072

Genes

EEA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18503760-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function.PMID 18503760Read ↗

Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.Semantic proximity Read ↗

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PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.Semantic proximity Read ↗

Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress.Semantic proximity Read ↗

Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.Semantic proximity Read ↗

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