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Article

Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.

The Journal of biological chemistry - 11 Jul 2008

Adachi Naoko, Kobayashi Takeshi, Takahashi Hideyuki, Kawasaki Takumi, Shirai Yasuhito, Ueyama Takehiko, Matsuda Toshio, Seki Takahiro, Sakai Norio, Saito Naoaki

Abstract excerpt

Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disease caused by mutations in protein kinase Cgamma (PKCgamma). Interestingly, 18 of 22 mutations are concentrated in the C1 domain, which binds diacylglycerol and is necessary for translocation and regulation of PKCgamma kinase activity. To determine the effect of these mutations on PKCgamma function and the pathology of SCA14, we...

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PMID: 18499672
DOI: 10.1074/jbc.M801492200

Genes

TRPC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.PMID 18499672Read ↗

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