Article

The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

2024-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Mutations of KIF7 , a key ciliary component of Sonic hedgehog (SHH) pathway, are associated in humans with cerebral cortex malformations and clinical features suggestive of cortical dysfunction. KIF7 regulates the processing of GLI-A and GLI3-R transcription factors in a SHH-dependent manner both in humans and mice. Here, we examine the embryonic cortex development of a mouse model that lacks t...

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Literature Corpus work: 5ac563c8-6703-5c60-9a4d-7560c25abc9c
DOI: 10.1101/2024.03.21.586159

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