Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cleft Palate and Aglossia Result From Perturbations in Wnt and Hedgehog Signaling.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 May 2017

Yuan Gongjie, Singh Gurpreet, Chen Serafine, Perez Kristy Carrington, Wu Yan, Liu Bo, Helms Jill Ann

Abstract excerpt

OBJECTIVE: The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a. DESIGN: Kif3a mutant embryos and their littermate controls were analyzed for defects in facial development at multiple stages of embryonic development. Histology was employed to understand the effects of Kif3a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cilia
Share to Cleft Palate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Kinesins

Share to Neural Crest

Share to Staining and Labeling

Share to Tongue

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 27259005
DOI: 10.1597/15-178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cleft Palate and Aglossia Result From Perturbations in Wnt and Hedgehog Signaling.PMID 27259005Read ↗

A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.Semantic proximity Read ↗

A tissue-specific role for intraflagellar transport genes during craniofacial developmentSemantic proximity Read ↗

Cilia-dependent GLI processing in neural crest cells is required for tongue development.Semantic proximity Read ↗

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.Semantic proximity Read ↗

Unmasking the ciliopathies: craniofacial defects and the primary cilium.Semantic proximity Read ↗

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.Semantic proximity Read ↗

Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signalingSemantic proximity Read ↗

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of functionSemantic proximity Read ↗

Coordinated multiple cellular processes in tongue developmentSemantic proximity Read ↗

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.Semantic proximity Read ↗

Role of epidermal primary cilia in the homeostasis of skin and hair follicles.Semantic proximity Read ↗

Craniofacial ciliopathies: A new classification for craniofacial disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.